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For gaining lean muscle mass and strength in the gym, SARMs users anecdotally recommended that Testolone be taken at 5 mg to 30 mg daily for 8 to 16 weeks, a recommendation supported by the Cochrane Database in Clinical Practice (RCT) for the prevention and treatment of sarcopenia, which could result from the use of this hormone/sarminabutanol combination. We designed a double-blind, placebo-controlled trial to investigate the safety and efficacy of Testolone for preventing muscle wasting in older men with mild-to-moderate sarcopenia. Methods We conducted a randomized, placebo-controlled, 2-week treatment protocol including 2 dose levels of Testolone (30 mg and 45 mg), each with an independent risk-adjustment strategy by one author (CC), moobs definition. Written informed consent was obtained from all study participants and all procedures were performed in accordance with the tenets of the Declaration of Helsinki. Study population The primary endpoint was change in muscle area measured as percent body fat loss of at least 10% and/or reduction of fat mass > 10% as assessed by DXA using a previously validated criteria.17, 18 The secondary endpoints (strength and lean mass and changes in lean and strength mass) were assessed by the same DXA test (DEXA-100) from DXA-400 to 100. We selected the criteria because DXA-100 is commonly used to measure resting muscle area while DXA-400 to 100 measures resting muscle mass, store sarms 5. Furthermore, these were not specific parameters of muscle mass; therefore, the outcome measurement of strength was deemed appropriate to better characterize the changes in lean mass. Secondary endpoints, i.e., changes in lean mass and strength, were measured by the same DXA test (DEXA-100) that was utilized to assess muscle mass. The study subjects were participants with moderate to severe sarcopenia, defined as a decrease in muscle fiber cross-sectional area of at least 10% and a reduction in fat mass > 10% as assessed by DXA, using the same test for muscle cross-sectional area as used previously to assess changes in strength,18. This subset was eligible to include as a control group in the study by excluding participants who were already participating in another study or did not wish to participate as the primary endpoint (n = 26), as they were not receiving Testolone (≤ 5 mg per day) and did not meet the criteria for sarcopenia (n = 22). Assessment of muscle mass
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